Abstract

Background: Pharmacists play vital role in health care system; they help to prevent medication errors. At discharge from health care facility 20% to 70% patients have at least one medication discrepancy. Pharmacist has direct impact on reducing readmission in hospitals as well as emergency visits. There is substantial reduction of 67%, 28% and 19% in adverse drug event-related to hospital revisits, (ED) visits and hospital readmissions. Objectives: To determine the Impact of pharmacist led pharmaceutical care on patient medication therapy by comparing PROMPT-QOL between pharmaceutical care (PC)
patients and usual care (UC) patients. Also to compare the characteristics of participants between PC and UC groups. Methods: A randomized controlled trial was conducted at tertiary care hospital in Pakistan, Rawalpindi from May to October 2020.A total of 300 patients were randomly allocated into
UC (N = 150) and PC (N = 150) groups respectively, the follow up period was one month. Results: Independent Sample t-test results showed that post intervention in pharmaceutical care group had significantly higher mean changes in 8 Domains of PROMP- QOL than in usual care group. The Domains were MDI (Medicine and Disease Information), SME(Satisfaction of Medicine Effectiveness), IMS (Impacts of medicines and Side effects), PIMU (Psychological Impacts of Medication Use), CON (Convenience), AA (Availability and Accessibility), TRHC (Therapeutic Relationships with Health care providers) and OQOL (Overall quality of life) with p-value <0.005.In Demographic characteristics, gender variable is significantly different between two groups (p-value <0.001). The other variables found to be similar in both PC and UC groups.

Conclusions: Pharmacist oriented pharmaceutical care could improve patient medication therapy related to quality of life hence there is a need of proper pharmacist counseling room in at least tertiary care hospitals so that patient can better understand medication to improve quality of life. Eight domains of PROMPT-QOL showed significant results and were sufficient to assess humanistic impact of pharmaceutical care.

Abstract

Background
As we know that allergies all over the world is the utmost medical problem and in Karachi, Pakistan, every 2nd person is complaining of allergy due to
pollution. Antihistamines are considered as one the most widely used and abused medications after analgesics. Antihistamines are generally used in
the palliative treatment in allergic condition like hay fever urticaria. Some of pruritus, rhinitis, conjunctivitis, nasal discharge, mild asthma etc.
Methodology The study conducts among the population of Karachi to check awareness regarding antihistamine and its complication i.e. sedation affect daily
routine or not. This may help to estimate the level of awareness among the population of Karachi towards the usage of these drugs and accordingly
enable us to make efforts to improve the same. Result Total no of participants is 470 that responded to the survey, and the finding
indicated that the main antihistamine used is cetirizine and loratadine. A proportion of 91.5% of total number of respondent have used antihistamine
for allergic disease and have information about antihistamine medications and 8.5% had used antihistamine for allergic diseases while 53.2% used
antihistamine as a OTC drug and 45.8% used as a prescription drug.31.9% have experienced sedation after using antihistamine while 44.7% have not experienced any sedative effect. Nearly 23.4% not aware of the sedative effect of antihistamine. CONCLUSION The most used antihistamine is cetirizine and loratadine and the most participants have information regarding the complications and the side effects of antihistamine in general. 

Abstract

--------