Abstract

The present investigation deals with development and evaluation of mucoadhesive gastroretentive tablet of Norfloxacin using natural polymer from Tamrind seed polysaccharide. Natural polymers have been used widely in the sustained release of a variety of drugs to enhance their release patterns. The hypothesis behind this work is to increase the bioavailability of drug by gastro retentive approach. Different formulations (F1 to F12) have been prepared by wet granulation method. Preformulation studies such as melting point, U.V. scanning, solubility studies have been done. Drug polymer compatibility studies were done using FT-IR. Micromeretic studies such as bulk density, tapped density, carr’s index, hausner ratio and angle of repose were performed. Prepared tablets were further evaluated for mucoadhesive strength, swelling index, hardness, weight variation, friability, thickness has also been evaluated. The in- vitro drug release studies has been done or 8hrs by using USP-II apparatus with 0.1 N HCl. Different kinetic models were applied to study the release pattern of drug from the tablet. Based on the results of different studies formulation F10 was selected as best formulation. All the parameters were found within the acceptance limit and the formulated tablet shows extended release for 8 hrs.