DESIGN AND DEVELOPMENT OF ZIPRASIDONE FAST DISSOLVING TABLETS BY VACUUM DRYING TECHNIQUE

Abstract

The objective of this research was to formulate fast dissolving tablet of Ziprasidone for rapid action. Vacuum drying method was adapted to prepare the tablets by using two different Sublimating agents. All formulations are evaluated for pre and post-compression parameters like Angle of repose, Bulk density, Tapped density, Housners ratio, Hardness, Weight variation, wetting time, water absorption ratio, Disintegration time, Drug content. The results obtained showed that the quantity of camphor significantly affect response variables. The results indicate that the optimized tablet formulation provides a short DT of 13 sec with sufficient crushing strength and acceptable friability.