SOLUBILITY ENHANCEMENT OF CARVEDILOL USING LIQUISOLID COMPACT TECHNIQUE

2012-01-10 2012-01-15 2012-01-20 3/22/2025 12:17:45 PM Journal of Applied Pharmacy 4 2012 Original research article 103 108 2012 JAppPharm (2012 ). 4. 103-108 https://doi.org/10.21065/19204159.4.103 English Tarique Ali Meer, Ajay Sav, Purnima Amin Solubility Enhancement, Liquisolid Compacts, BCS Classification, Carvedilol A novel liquisolid compact technique was used for soulbility enahncement of poorly water soluble drug carvedilol (CAR). CAR was dissolved in water miscible non volatile solvent and then adsorbed on a solid carrier which was later compacted with other excipient into a tablet. The tablets were characterized with respect to hardness, friability, disintegration and in-vitro dissolution profile. Effect of storage conditions on dissolution profile was also studied. DSC and XRD studies were done to confirm the physical state of CAR in the formulation.