SYNTHESIS, ANTIBACTERIAL, AND ANTIFUNGAL EVALUATION OF NOVEL MANNICH BASES CONTAINING OXADIAZOLE AND

2013-06-10 2013-06-15 2013-07-15 3/2/2025 2:28:03 AM Journal of Applied Pharmacy 5 2013 Original research article 76 88 2013 JAppPharm (2013 ). 5. 76-88 https://doi.org/10.21065/19204159.5.76 English Maliki Reddy Dastagiri Reddy, Aluru Raghavendra Guru Prasad, ... 1,3,4-oxadiazole moiety; Pyrazole-3-one moiety; Antibacterial activity; Antifungal activity; Minimum inhibitory concentration Purpose: To synthesize novel series of compounds containing 1,3,4-oxadiazole and pyrazole-3-one moieties in good yields and to evaluate the antimicrobial activity of title compounds. Methods: Title compounds were characterized by IR, 1H NMR and mass spectra and evaluated for their antimicrobial activities against certain selected gram-positive bacteria, gram-negative bacteria and fungi by disk diffusion method and broth dilution method. Results: Fluoro, chloro, bromo, nitro, morphonilyl, piperizynyl, N-methylpiperizine substituted compounds (VII c, d, e, f, i, j and k) showed more antimicrobial activity against than other compounds of the series. Conclusion: Antimicrobial activity was expressed as the corresponding minimum inhibitory concentration (MIC). The compounds have demonstrated considerable antibacterial and antifungal activities.